Recovery & Repair
KPV
KPV — Lysine-Proline-Valine (the tail end of the alpha-MSH hormone)
Calming inflammation in the gut and skin
Quick answer
A 10 mg vial with 2 mL of bacteriostatic water makes 5 mg/mL. A 500 mcg dose is 10 units on a U-100 syringe. Most research runs 4 to 8 weeks, once a day.
- Mix it
- 10 mg vial + 2 mL water
- Draw
- About 10 units on a U-100 syringe
- How often
- Once a day
- How it is given
- Under the skin. Some research uses it by mouth or on the skin.
- How long it lasts
- Short. It clears within hours, so it is usually dosed daily.
- Store it
- Refrigerate after mixing. Use within about 4 weeks.
What it is
Full name: KPV — Lysine-Proline-Valine (the tail end of the alpha-MSH hormone). Most people write it as KPV.
KPV is a three amino acid peptide taken from the end of a natural hormone called alpha-MSH. Research looks at how it quiets inflammation signals in the gut lining and in skin.
What it is studied for
- Gut irritation and bowel inflammation
- Inflamed or itchy skin
- Wound healing
- General inflammation research
These are things researchers study. They are not promised results.
Dosing at a glance
These are the amounts used most often in research. Always start at the low end.
- Vial size
- 10 mg
- Dose range
- 200 mcg to 500 mcg per dose
- How often
- Once a day
- Cycle length
- 4 to 8 weeks
- Mix with
- Bacteriostatic water usually works. If the powder stays cloudy or will not dissolve, 0.6% acetic acid is the normal fix. See the mixing guide.
- Storage
- Refrigerate after mixing. Use within about 4 weeks.
Week by week
A common way researchers step the dose up. Stay at each step until it feels easy.
| When | Dose | Notes |
|---|---|---|
| Week 1 | 200 mcg once a day | Start low and watch how you feel. |
| Weeks 2-6 | 500 mcg once a day | Main phase. |
| Weeks 7-8 | 500 mcg every other day | Taper, then take a break. |
This is a reference schedule, not a prescription. Start at the lowest step.
Mixing it
A common setup for KPV is a 10 mg vial with 2 mL of bacteriostatic water.
That makes 5 mg per mL. A 500 mcg dose is about 10 units on a standard insulin syringe.
About the liquid: Bacteriostatic water usually works. If the powder stays cloudy or will not dissolve, 0.6% acetic acid is the normal fix. See the mixing guide.
Open this in the calculatorWhat to watch for
- Mild injection site redness
- Loose stools in the first week
Stop and speak to a clinician if anything feels wrong. See the safety page.
Common questions
Why does my KPV look cloudy?
KPV does not always dissolve in plain bacteriostatic water. A 0.6% acetic acid solution is the usual answer.
Is KPV the same as the K in KLOW?
Yes. KLOW is the GLOW blend with KPV added.
How long until anything changes?
Research reports slow change. Give it 3 to 4 weeks.