Metabolic
GLP-2 TZ (Tirzepatide)
Tirzepatide
Appetite, blood sugar, and weight research
Quick answer
A 30 mg vial with 3 mL of water makes 10 mg/mL. A 2.5 mg dose is 25 units. Once a week, stepped up every 4 weeks.
- Mix it
- 30 mg vial + 3 mL water
- Draw
- About 25 units on a U-100 syringe
- How often
- Once a week, same day each week
- How it is given
- Under the skin, same day each week.
- How long it lasts
- About 5 days, which is why it is once a week.
- Store it
- Refrigerate after mixing. Use within about 4 weeks.
What it is
Full name: Tirzepatide. Most people write it as GLP-2 TZ.
Tirzepatide acts on two gut hormone pathways at once, GLP-1 and GIP. Research looks at appetite, how full you feel, and blood sugar control.
What it is studied for
- Appetite and portion size
- Body weight
- Blood sugar control
- Food noise and cravings
These are things researchers study. They are not promised results.
Dosing at a glance
These are the amounts used most often in research. Always start at the low end.
- Vial size
- 10 mg to 30 mg
- Dose range
- 2.5 mg to 15 mg per week, increased slowly
- How often
- Once a week, same day each week
- Cycle length
- Long term, dose stepped up every 4 weeks
- Mix with
- Bacteriostatic water (also called BAC water or reconstitution solution).
- Storage
- Refrigerate after mixing. Use within about 4 weeks.
Week by week
A common way researchers step the dose up. Stay at each step until it feels easy.
| When | Dose | Notes |
|---|---|---|
| Weeks 1-4 | 2.5 mg weekly | Starting dose. Do not skip it. |
| Weeks 5-8 | 5 mg weekly | Only if week 4 felt fine. |
| Weeks 9-12 | 7.5 mg weekly | Step up slowly. |
| Week 13+ | 10-15 mg weekly | Stay at the lowest dose that works. |
This is a reference schedule, not a prescription. Start at the lowest step.
Mixing it
A common setup for GLP-2 TZ is a 30 mg vial with 3 mL of bacteriostatic water.
That makes 10 mg per mL. A 2.5 mg dose is about 25 units on a standard insulin syringe.
Bacteriostatic water is all you need here. Acetic acid is only for powders that will not dissolve. See the mixing guide.
Open this in the calculatorWhat to watch for
- Nausea, especially in the first week of a new dose
- Constipation and low appetite
- Dehydration if you forget to drink water
Stop and speak to a clinician if anything feels wrong. See the safety page.
Common questions
What if I miss a dose?
Take it within 4 days. Otherwise skip it and go back to your normal day.
Why so much nausea?
Usually the dose went up too fast. Hold at the current step for another 4 weeks.
Will I lose muscle?
You can. Eat protein and keep lifting.